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KMID : 1100920230440010002
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Korean Journal of Family Medicine
2023 Volume.44 No. 1 p.2 ~ p.10
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Angiotensin-Converting Enzyme Inhibitor-Induced Non-allergic Perioral Angioedema: A Case-Based Scoping Review
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Pitak-Arnnop Poramate
Subbalekha Keskanya
Muangchan Chayawee
Auychai Prim
Sirintawat Nattapong
Meningaud Jean-Paul
Neff Andreas
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Abstract
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Patients with angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema (ACEIIA) may visit family physicians. The aim of this article was to describe a case of delayed-onset ACEIIA and to present a concise scoping review. Using a case report and a scoping review study design, we report a case of ACEIIA, with clinically confirmed diagnosis. The symptoms resolved after replacing the offending ACEI with another antihypertensive agent. After excluding other causes of perioral swelling and discontinuation of ACEI, the patient was symptom-free within a few days thereafter. Based on this case presentation, we performed a meta-narrative scoping review including up-todate diagnosis and management of ACEIIA, based on published data in English, French, and German from inception to April 1, 2021. Patients with angioedema of unknown origin should be cautiously examined to rule out oral diseases, including allergy to dental materials and drug-induced angioedema. Clinicopathological aspects and current treatment guidelines for ACEI-associated angioedema are also presented.
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KEYWORD
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Angioedema, Angiotensin-Converting Enzyme Inhibitors, Oral Medicine, Review
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